Focused Issue: Global Urology by Drs. Gopal H. Badlani and Sakti Das

This is an attempt to bridge that gap through a focused issue on male health. The war in the middle-East has created a need for reconstruction in the field of urology as the genital trauma was a prominent feature in the wounded warriors. Regenerative medicine competes with transplant to fill this void, as do the Eastern aphrodisiacs with new pharmacological advances for male sexual dysfunction. Testosterone replacement has seen its ups and downs, the current dilemma and its global use are highlighted.

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Focused Issue: Chronic Orchialgia by Drs. Ryan P. Smith and Raymond A. Costabile

It is our pleasure to present this introduction to a special issue of Translational Andrology and Urology (TAU) that is focused on “Chronic orchialgia”. As editors, our goal was to present a current, state-of-the-art and lucid perspective on this common and challenging condition. Established national experts, thought leaders, and rising stars in Andrology were invited to contribute and their efforts have coalesced into a comprehensive edition beginning with a description of the pervasiveness of this condition and ending with a thorough characterization of the psychological correlates which can co-manifest with this disease process.

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Focused issue: Erectile Dysfunction

Scientific evaluation in this field is needed to increase our knowledge and foster evidence-based best practice in men with ED. The current state of ED research is exciting and, in this issue, we present the state of art papers that address various aspects in medical and surgical management of ED. We aim to address the various controversies surrounding key issues such as reviewing the current evidence to support penile rehabilitation; examining the facts on ED, endothelial dysfunction and cardiovascular disease; raising awareness on the risks of counterfeit ED medications; exploring new pharmacotherapeutic agents; and revisiting the advances in the last 40 decades in penile prosthesis implant surgery.

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2016 Annual Report of TAU

Greetings from Prof. Ying-Lu Guo, Prof. Tom F. Lue and Editorial Office of TAU！

We are glad to present the 2016 Annual Report of TAU here. In 2016, the citations of TAU has increased significantly and TAU has been indexed in ESCI. More information is shown in the Annual Report.

We would like to express sincere appreciation for the enthusiastic and vigorous support and contributions from all board members, guest editors, reviewers, authors, readers, etc. We wish you a happy and prosperous 2017!    Read More>>

Ejaculatory Dysfunction

Over the past two decades our understanding of ejaculatory dysfunction has evolved from the initial premise that these conditions were almost exclusively due psychological factors to a new understanding. We now understand that men with lifelong premature ejaculation may have an underlying genetic predisposition to rapid ejaculation and that men with acquired premature ejaculation may have, in addition to a variety of psychorelational factors including global anxiety, sexual performance anxiety and depression, be also suffering comorbid erectile dysfunction, chronic prostatitis and a variety of less common conditions including hyperthyroidism.

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Testimonials from Prominent Physician Investigator

Prominent physician investigators, including editorial board members, authors, and readers, who know the journal well, provided testimonials for TAU. We are thankful for their support for the journal.

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Focused Issue: Interstitial Cystitis/Painful Bladder Syndrome edited by Drs. Grannum R. Sant and Ricardo Saban

Dr. Grannum R. Sant（Left）. Guest editor of focused issue “Interstitial Cystitis/Painful Bladder Syndrome” , Tufts University School of Medicine, USA. Dr. Ricardo Saban(Right). Guest editor of focused issue “Interstitial Cystitis/Painful Bladder Syndrome”, University Anhembi Morumbi, S. Paulo, Brazil. Dr. Sant and Saban strove to present a current, state-of-the-art and global perspective on this chronic and potentially debilitating disease. The papers in this focused issue of the TAU journal issue provide insightful updates and perspectives on the epidemiology, pathophysiology and mechanistic aspects of this enigmatic disease, overviews of IC diagnosis and treatment in India and Japan and patient advocacy group contributions from the US and European Union (EU).

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Focus issue: Testosterone Replacement Therapy edited by Drs. Daniel A. Shoskes and Lawrence S. Hakim

It is a pleasure to present this introduction to a very special issue of Translational Andrology and Urology (TAU) that is focused on “testosterone replacement therapy” (TRT). As editors, we strove to present a current, state-of-the-art and global perspective on this very common and important medical condition. Established national and international experts as well as rising stars were invited to contribute and the response to our invitations to provide manuscripts on this timely subject has been overwhelming and allowed for the inclusion of numerous outstanding original articles, comprehensive review articles, as well as important opinions from many of the world leaders in the area of andrology.

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Focus issue: Urothelial Carcinoma edited by Drs. Shahrokh F. Shariat and Romain Mathieu

This special issue addresses some of the most exiting contemporary concepts and controversies in UC. Dr. Nyirady, a leading authority in the management of UC, describes the differences between bladder and UTUC. Dr. van Rhijn, a foremost expert in the biology of UC, discusses the genetic and biological markers that could help us guide early diagnosis and clinical decision-making in urachal cancer, a specific type of bladder cancer.

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Increased bladder permeability in interstitial cystitis/painful bladder syndrome

Finding effective treatments would be greatly improved if patients could be stratified into more homogeneous groups for clinical trials. An effective method of measuring bladder permeability could also represent an important step forward in this regard because it could offer an improved diagnostic as well as an objective measure of response to therapy that could be used to optimize therapies. Our group has recently shown that MRI can clearly demonstrate increased bladder permeability that correlates with patient condition. The mechanisms by which information concerning the status of one pelvic organ is communicated to another, and how this information affects the other organ is critical to know and is being actively investigated by a number of groups. Finally, understanding the role of the brain, stress, and past life experiences also needs to be investigated.

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Clinical presentation and treatment of bladder pain syndrome/interstitial cystitis (BPS/IC) in India

Hunner’s lesion is a distinctive inflammatory lesion with characteristics central fragility, which ruptures on hydrodistension. It is usually a solitary lesion but 2-3 lesions may be present. This lesion is typically visible before the bladder is distended. On cystoscopy, it appears as a circumscript reddened mucosal area with small vessels radiating towards a central scar. This site ruptures with increasing bladder distension; with petechial oozing blood from the lesion in a waterfall fashion. In our series of more than 250 cystoscopies in BPS/IC patients, a typical Hunner’s lesion has rarely been observed. In our series we have seen red patches but accompanied by patechiae and ecchymosis all over the bladder and not sure if it is Hunner’s lesion.

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A step forward: Translational Andrology and Urology is indexed in PubMed/PMC

By December 5th, 2015, the Translational Andrology and Urology (TAU) has passed all the evaluation required by PubMed Centre (PMC) and is officially accepted for inclusion in PubMed/PMC - an extensive and important biomedical online journal repository. All previously published content on TAU will be searchable within 1-2 months. Consequently, authors publishing in TAU will enjoy maximum exposure of their research. Acceptance in this prominent database speaks highly to the quality of the published work and the journal’s significant potential.

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Urodynamic and physiologic patterns associated with the common causes of neurogenic bladder in adults

Schematic showing the determination of detrusor pressure or Pdet. The detrusor contribution to voiding is calculated by subtracting the abdominal pressure (Pabd; estimated as rectal pressure) from total intravesical pressure (Pves).

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Management options for sphincteric deficiency in adults with neurogenic bladder

Young–Dees–Leadbetter repair—involves lengthening the urethra, often some narrowing up to or including the trigone, with excision of bladder mucosa and wrapping of the repair with detrusor muscle leaflets.

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