O 24. Sebaceous carcinoma of the penis: Case report and literature review

Objective: To improve the understanding of penile sebaceous carcinomas (SC).

Methods: One case of penile sebaceous carcinomas was reported. The pathogenic mechanism, clinical manifestation, pathologic features, diagnosis and treatment of this disease were reviewed and discussed with the relevant literature.

Results: The 78-year-old-male patient was admitted with the disease history of the progressively enlargement node on the right side of coronary sulcus with pain for 4 months. Moderately differentiated squamous carcinoma of penis was indicated by biopsy, and Partial amputation of the penis plus left side inguinal lymph node biopsy was performed. The diagnosis by postoperative pathology was moderately differentiated, exogenic SC (pT3N2M0) with 5 in 6 inguinal lymph nodes in right side invasion by biopsy. One year after surgery, the patient died with systemic metastases.

Conclusions: SC of penis is extremely rare and is also a very aggressive malignant tumor on the penis, presenting bilateral inguinal lymph nodes metastases in the early phase. It should be considered in the differential diagnosis of patients presenting with squamous carcinoma of the penis. A thorough histological and immunohistochemical examination is required to make the diagnosis. The optimal treatment for sebaceous carcinoma of the penis has not been established. Surgical resection with a generous clear margin and systematic bilateral inguinal lymphadenectomy should be performed to avoid local recurrence and regional lymphatic tumoral propagation.