RU 19. Relationship of STAT3, VEGF and MVD expression in adrenal cortical carcinoma
Research Urology

RU 19. Relationship of STAT3, VEGF and MVD expression in adrenal cortical carcinoma

Yu Zhu1, Jia-Yan Sheng1, Yun-Ze Xu1, Yu-Xuan Wu1, Ju-Ping Zhao1, Hong-Chao He1, Fei Yuan2, Wen-Bin Rui1, Cong-Yu Zhang1, Jun Ji3, Fu-Kang Sun1, Wen-Long Zhou1, Xin Xie1, Zhou- Jun Shen1, Xiao-Long Jin2

1Department of Urology, China; 2Department of Pathology, China; 3Department of General Surgery, Ruijin Hospital, Medical School Shanghai Jiaotong University, Shanghai 200025, China

Objective: To investigate the expression of signal transducers and activators of transcription 3(STAT3), vascular endothelial growth factor (VEGF) and microvessel density (MVD) in adrenal cortical carcinoma (ACC) as well as to discuss their clinical significance.

Methods: 37 adrenal cortical neoplasm specimens resected from patients were divided into two groups, 20 in the benign group and 17 in the malignant group (adrenal cortical carcinoma, ACC group). The expressions of STAT3, VEGF and MVD were detected by immunohistochemical staining.

Results: STAT3 was highly expressed in ACC group (11/17, 64.71%), lowly in benign group (4/20, 20.00%), with significant difference noted (P<0.05); VEGF staining was seen in 70.59% (12/17) of the malignant cases versus 25.00% (5/20) of the benign, with significant difference noted (P<0.01); MVD in adrenocortical carcinoma was higher than those in adrenocortical adenoma (76.40±15.64 vs. 21.05±8.07), with significant difference (P<0.05). STAT3 expression both in benign and malignant adrenal neoplasm were positively correlated with VEGF, and VEGF expression were positively correlated with MVD.

Conclusions: The high expression of STAT3, VEGF in ACC contribute to tumor angiogenesis. We provide the theoretical evidence for anti-angiogenesis regime in ACC.

Key words

STAT3; VEGF; MVD; adrenal cortical carcinoma

DOI: 10.3978/j.issn.2223-4683.2012.s200

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