Objective: To investigate the expression of signal transducers and activators of transcription 3(STAT3), vascular endothelial
growth factor (VEGF) and microvessel density (MVD) in
adrenal cortical carcinoma (ACC) as well as to discuss their
Methods: 37 adrenal cortical neoplasm specimens resected from
patients were divided into two groups, 20 in the benign group
and 17 in the malignant group (adrenal cortical carcinoma,
ACC group). The expressions of STAT3, VEGF and MVD were
detected by immunohistochemical staining.
Results: STAT3 was highly expressed in ACC group (11/17,
64.71%), lowly in benign group (4/20, 20.00%), with significant
difference noted (P<0.05); VEGF staining was seen in
70.59% (12/17) of the malignant cases versus 25.00% (5/20)
of the benign, with significant difference noted (P<0.01);
MVD in adrenocortical carcinoma was higher than those
in adrenocortical adenoma (76.40±15.64 vs. 21.05±8.07),
with significant difference (P<0.05). STAT3 expression both
in benign and malignant adrenal neoplasm were positively
correlated with VEGF, and VEGF expression were positively
correlated with MVD.
Conclusions: The high expression of STAT3, VEGF in ACC
contribute to tumor angiogenesis. We provide the theoretical
evidence for anti-angiogenesis regime in ACC.