AB091. C1QBP suppresses cell adhesion and metastasis of renal carcinoma cells

Background: Complement component 1q subcomponent binding protein (C1QBP) is a ubiquitously expressed cellular protein and can be upregulated or activated in a variety of malignant tumors, including those from thyroid, colon and breast, but its role remains unclear in renal cell carcinoma (RCC).

Methods: In this study, we constructed C1QBP knockdown RCC cell line. Microarray assay was used to analyze C1QBP regulated genes. Cell adhesion and migratory was tested.

Results: C1QBP knockdown influenced expression of multiple genes associated with cell adhesion. Cell invasion abilities were significantly increased with increased metastasis to lung and liver in vivo. C1QBP may regulate RCC cell adhesion and invasion through influencing the p-GSK3/β-catenin/L1CAM expression.

Conclusions: Overall, our study demonstrated that C1QBP could regulate RCC metastasis by regulating the GSK3/β-catenin/L1CAM signaling pathway.

Keywords: Complement component 1q subcomponent binding protein (C1QBP); L1CAM; renal cell carcinoma (RCC)