AB049. Prognostic scores based on the preoperative plasma fibrinogen and serum albumin level as a prognostic factor in patients with upper urinary tract urothelial carcinoma

Background: To clarify the prognostic value of preoperative plasma fibrinogen and serum albumin level, as known as FA score, in a cohort of Chinese patients with upper urinary tract urothelial carcinoma (UTUC).

Methods: The FA score was calculated based on optimal cutoff values of 3.53 g/L for fibrinogen and 43.56 g/L for albumin. Overall survival (OS) and cancer specific survival (CSS) was assessed using the Kaplan-Meier method and the equivalences of the survival curves were tested by log-rank tests.

Results: In univariate analysis, Tumor size, tumor grade, T stage and preoperative FA score were significantly associated with OS and CSS, and multivariate Cox proportional hazards regression analysis identified FA score was an independent predictor for OS and CSS.

Conclusions: The evaluation of preoperative FA score can be regarded as an independent prognostic factor for predicting OS and CSS of patients with UTUC. The fibrinogen and albumin levels are low cost, routine measured and easy accessibility in clinical practice.

Keywords: Urinary tract urothelial carcinoma (UTUC); plasma fibrinogen; serum albumin; prognosis