Sperm DNA fragmentation: a rationale for its clinical utility

Ahmad Majzoub, Ashok Agarwal, Sandro C. Esteves


We read with great interest the commentary written by Akanksha Mehta on the “Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios” by Agarwal et al. (1). The author acknowledges the impact of sperm DNA fragmentation (SDF) on male fertility potential; however, she highlights important obstacles that remain to be considered during the utility of SDF testing in clinical practice such as: absence of cutoff values, cost of the test and the lack of solid evidence recommending the routine use of SDF.