Development of targeted therapeutic strategies and refinement of sperm DNA fragmentation testing

Ashok Agarwal, Chak-Lam Cho, Ahmad Majzoub, Sandro C. Esteves


We read with interest a well written and insightful commentary by Drs. Christensen and Humaidan. The authors strongly endorsed the sperm DNA fragmentation (SDF) practice recommendations of Agarwal et al. (1) and raised some important aspects regarding the testing of SDF (2) such as: (I) possible mechanism to explain the implication of SDF on the reproductive outcome; (II) ideal treatment strategies for SDF; and (III) laboratory methodology for SDF.