AB216. Presence, localization, and origin of clusterin in normal human spermatozoa
Abstract publication Basic research

AB216. Presence, localization, and origin of clusterin in normal human spermatozoa

Zhijian Han, Zengjun Wang, Gong Cheng, Bianjiang Liu, Pengchao Li, Jie Li, Wei Wang, Changjun Yin, Wei Zhang

Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Abstract: Purpose clusterin in mammalian semen is a secretory form of clusterin (sCLU) with the heterodimeric structure. It is secreted by the epididymis and seminal vesicle. It is generally agreed that clusterin mainly exists on the surface of abnormal spermatozoa and is implicated in decreased sperm motility, sperm aggregation and infertility. However, few studies observe clusterin in normal spermatozoa, which is presumed to be a novel form. Up to now, the systematical information about the presence, localization, origin and function of clusterin in normal human spermatozoa has yet not been established. The aim of our current study is to systematically research clusterin in normal human spermatozoa.

Keywords: Cluster; normal human spermatozoa; presence; localization; origin

doi: 10.3978/j.issn.2223-4683.2014.s216

Cite this article as: Han Z, Wang Z, Cheng G, Liu B, Li P, Li J, Wang W, Yin C, Zhang W. Presence, localization, and origin of clusterin in normal human spermatozoa. Transl Androl Urol 2014;3(S1):AB216. doi: 10.3978/j.issn.2223-4683.2014.s216

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