%0 Journal Article %T Cholesterol pathway the Achilles heel in prostate cancer metastasis %A Heidegger, Isabel %A Pichler, Renate %A Pircher, Andreas %J Translational Andrology and Urology %D 2018 %B 2018 %9 %! Cholesterol pathway the Achilles heel in prostate cancer metastasis %K %X We read with great interest the research article by Chen et al . (1) published in a previous issue of Nature Genetics as well as the featured article in the “clinical implication for basic research section” of the New England Journal of Medicine by Abate-Shen (2) arguing that the lipogenic program is essential for promotion of metastatic prostate cancer (PC) formation. Chen et al . provide profound genetic data that loss of PTEN and PML induce a sterol regulatory element binding protein (SREBP) dependent lipogenic program leading to formation of more aggressive PC phenotypes. %U https://tau.amegroups.org/article/view/20803 %P S686-S687 %@ 2223-4691