TY - JOUR AU - Kovac, Jason R. PY - 2017 TI - Practical considerations for DNA fragmentation testing in the management of male fertility JF - Translational Andrology and Urology; Vol 6, Supplement 4 (September 30, 2017): Translational Andrology and Urology (Sperm DNA Fragmentation) Y2 - 2017 KW - N2 - Over the past decade, the importance of DNA fragmentation has matured as more studies suggested a role in the management of male fertility. As a measure of spermatogenic damage from reactive oxygen species (ROS), DNA fragmentation occurs primarily during posttesticular processing through the epididymis (1,2). Given that spermatozoa are exquisitely sensitive to oxidative stress, varicoceles, a known cause of elevated ROS levels, are theorized to be one of the major contributors. UR - https://tau.amegroups.org/article/view/14615