Mast cell activation syndrome in pain syndromes bladder pain syndrome/interstitial cystitis and vulvodynia

Sigrid Regauer


In the short article by Prof. Ratner on mast cell activation syndrome and its overlooked or dismissed possible contribution to bladder pain syndrome/interstitial cystitis (BPS/IC) (1), the author outlines that increased numbers of activated mast cells (mast cell activation syndrome) may play a role in the development of painful BPS/IC. This association has been long recognized by the European Society for the Study of Interstitial Cystitis (ESSIC) which proposes mast cell counts in the detrusor muscle with a density >28 mast cells/mm2 as diagnostic criterion for BPS/IC (2).