Prediction of survival in patients with upper tract urothelial carcinoma
Letter to the Editor

Prediction of survival in patients with upper tract urothelial carcinoma

Boda Guo1,2^, Ming Liu1,2^

1Department of Urology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China; 2Graduate School of Peking Union Medical College, Beijing, China.

^ORCID: Boda Guo, 0000-0001-8373-4584; Ming Liu, 0000-0001-9557-5488.

Correspondence to: Ming Liu, MD. Department of Urology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China. Email: liumingbjhu@126.com.

Response to: Qi F, Wei X, Zheng Y, et al. Nomograms to predict overall and cancer-specific survival in patients with upper tract urothelial carcinoma: a large population-based study. Transl Androl Urol 2020;9:1177-91.


Submitted Oct 11, 2020. Accepted for publication Dec 11, 2020.

doi: 10.21037/tau-20-1331


With considerable interest, we read the article published by Qi et al. (1), who developed nomograms to predict the survival outcomes of patients with upper tract urothelial carcinoma (UTUC). This particular topic is an important clinical issue. As such, there are a few points that we would like to bring up.

  • The study included patients whose UTUC was the first tumor but did not take into account the risk of subsequent neoplasms following UTUC. However, bladder cancer recurrence after surgery for UTUC is a frequent event, which may affect patients’ survival (2,3).
  • UTUC surgery in the Surveillance, Epidemiology, and End Results (SEER) database includes nephroureterectomy and segmental ureterectomy. Another SEER-based study has also proved that the prognosis of UTUC patients receiving these two types of surgical treatment is different (3). It would be more meaningful to stratify patients according to the type of surgery that they received; in this way, readers can easily see which surgical treatment improves UTUC patient’s survival better.
  • SEER database provides information of four metastatic sites (lung, liver, bone and brain), which could be considered for inclusion in Qi et al.’s survival models. This is because including these specific metastases sites rather than M1 stage into their prognostic model may improve its predictive ability to some extent.

Acknowledgments

Funding: None.


Footnote

Provenance and Peer review: This article was a free submission to the journal. The article has undergone external peer review.

Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tau-20-1331). The authors have no conflicts of interest to declare.

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.


References

  1. Qi F, Wei X, Zheng Y, et al. Nomograms to predict overall and cancer-specific survival in patients with upper tract urothelial carcinoma: a large population-based study. Transl Androl Urol 2020;9:1177-91. [Crossref] [PubMed]
  2. Lonerg Qi F, Wei X, Zheng Y, et al. Nomograms to predict overall and cancer-specific an PE, Porten SP. Bladder tumor recurrence after urothelial carcinoma of the upper urinary tract. Transl Androl Urol 2020;9:1891-6. [Crossref]
  3. Wu YP, Lin YZ, Lin MY, et al. Risk factors for bladder cancer recurrence survival in patients with upper-tract urothelial carcinoma. Tumori 2018;104:451-8. [Crossref] [PubMed]
Cite this article as: Guo B, Liu M. Prediction of survival in patients with upper tract urothelial carcinoma. Transl Androl Urol 2021;10(1):536-537. doi: 10.21037/tau-20-1331