RU 20. Expressions of IGF-2, VEGFR-2, PDGFR and HPA in adrenal cortical carcinoma: Relation and significance

Objective: To study the expressions of IGF-2, VEGFR-2, PDGFE and HPA in adrenal cortical carcinoma (ACC) as well as to discuss the clinical significance.

Methods: 37 adrenal cortical neoplasm specimens resected from patients were examined by immunohistochemistry for the expressions of IGF-2, VEGFR-2, PDGFR and HPA. The patients were divided in two groups (20 benign cases and 17 malignant cases).

Results: IGF-2 expressed highly in the ACC group (76.47%) and lowly in the benign group (5.00%), with significant difference (P<0.05). VEGFR-2 expressed highly in the ACC group (76.47%) and lowly in the benign group (25.00%), with significant difference noted (P<0.05). HPA expressed highly in the ACC group (94.12%) and lowly in the benign group (15.00%), with significant difference noted (P<0.05). The expression of PDGFR was no significant difference between ACC group and benign group (P>0.05).

Conclusions: The high expressions of IGF-2, VEGFR-2 and HPA in ACC contribute to tumor angiogenesis, which provide the theoretical evidence for anti-angiogenesis regime in ACC.