PE 10. A clinical observation of sertraline combined with stellate ganglion block in treatment of permature ejaculation

Objective: To investigate the efficacy and safety of sertraline combined with stellate ganglion block (SGB) in treatment of permature ejaculation (PE).

Methods: A total of 50 patients with PE were randomly enrolled into 2 groups, each including 25 members. Over a 4-week treatment period, the sertraline group took sertraline 50 mg once a day; and the combined group (Sertraline with SGB) were given both sertraline 50 mg once a day as well as SGB therapy tiwice a week. All patients finished PE questionnairs which includes 4 items (perceived control over ejaculation, personal distress related to ejaculation, satisfaction with sexual intercourse, interpersonal difficulty related to ejaculation), and estimated intravaginal ejaculation latency time (IELT) was recorded.

Results: After treatment, IELT increased for both group,from baseline were (4.34±2.12) and (3.65±2.23) min in sertraline group, (6.23±2.66) and (5.22±3.22) in combined group, respectively. Moreover, the improvements of IELT and PRO achieved were more satisfied in combined group than in sertraline group. The differences were significant.

Conclusions: The combination of sertraline with SGB was more effective in treatment of PE than sertraline monotherapy,which indicated that the combined theropy may provide a new way for treatment of PE.