Sperm DNA fragmentation: overcoming standardization obstacles

Ahmad Majzoub, Ashok Agarwal, Sandro C. Esteves


In his commentary on the “Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios” by Agarwal et al. (1), Dr. Jarvi acknowledged the utility of sperm DNA fragmentation (SDF) testing in the workup of male factor infertility. He recognized that there is a growing interest in this diagnostic modality among urologists and reproductive endocrinologists. This interest, as he considered, is attributed to the increasing number of publications exploring the utility of SDF in various infertility related circumstances, which necessitates need for clinical guideline articles that would serve to identify the precise indications for such testing.