One of the many missing links between infertility and sperm DNA fragmentation

Chak-Lam Cho, Ashok Agarwal, Ahmad Majzoub, Sandro C. Esteves


Dr. Harlev, in his commentary (1), largely supported the practice recommendations proposed by Agarwal et al. (2) and concluded by stating that sperm DNA fragmentation (SDF) testing is a step forward in the right direction. The author correctly identified the pitfalls of the current practice in the areas of unexplained male infertility (UMI) and recurrent pregnancy loss (RPL). We want to further elaborate and discuss these points.