Sperm DNA fragmentation: a rationale for its clinical utility

We read with great interest the commentary written by Akanksha Mehta on the “Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios” by Agarwal et al. (1). The author acknowledges the impact of sperm DNA fragmentation (SDF) on male fertility potential; however, she highlights important obstacles that remain to be considered during the utility of SDF testing in clinical practice such as: absence of cutoff values, cost of the test and the lack of solid evidence recommending the routine use of SDF.