William E. Grizzle, MD, PhD

Department of Pathology and Surgery, University of Alabama at Birmingham, Birmingham, AL, USA

Dr. William E. Grizzle, a board certified pathologist, currently is Professor of Pathology and Surgery at the University of Alabama at Birmingham (UAB). He directs a program in translational research for the Department of Pathology, he is a Senior Scientist of the UAB Comprehensive Cancer Center, and is Director of the Tissue Collection and Banking Facility. He is internationally recognized for his expertise in biorepository management, operations, and sciences and for techniques used in translational research including the use of histochemical and immunohistochemical techniques in evaluating disease processes and in the study of molecular biomarkers. His research interests include the developmental enzymology of the adrenal gland and of features of adrenal and ovarian neoplasia, exosomes, non-translatable RNAs (e.g., microRNAs), molecular imaging, the internal ribosomal entry site in translation and molecular features in the development and progression of epithelial cancers. His studies of molecular imaging include multi-parameter magnetic resonance imaging (mpMRI) fused with ultrasound to identify prostate cancer and multispectral optoacoustic tomography in the identification of a wide range of non-neoplastic diseases and malignant and benign neoplasias. 

He has published over 550 manuscripts, books and book chapters. He is principal investigator of the Southern Division of the Cooperative Human Tissue Network, the Tissue Processing Center of the Pulmonary Hypertension Breakthrough Initiative, and the Tissue Procurement Shared Facility of the Comprehensive Cancer Center. He is a former president and former vice president of the Biological Stain Commission (BSC); and currently is Trustee Emeritus. He is former president of the International Society of Biological and Environmental Repositories (ISBER). In 2005, he was selected as the Outstanding Member of the UAB Comprehensive Cancer Center. In 2007 and 2010, he was awarded NCI Leadership Awards Secondary for his work with the Early Detection Research Network (EDRN).  He received the 2015 ISBER Award for Outstanding Achievement in Biobanking. He presented numerous national and international workshops on biorepositories and translational research and has been a consultant on biorepositories to NIH (NHLBI, NCI, NIDDK), to numerous countries (currently, India), and to multiple US and International universities/institutions.