TY - JOUR AU - Janicki, Joseph J. AU - Gruber, Michele A. AU - Chancellor, Michael B. PY - 2015 TI - Intravesical liposome drug delivery and IC/BPS JF - Translational Andrology and Urology; Vol 4, No 5 (October 27, 2015): Translational Andrology and Urology (Interstitial Cystitis/Painful Bladder Syndrome: Part I) Y2 - 2015 KW - N2 - Intravesical therapy has previously shown to be effective in delaying or preventing recurrence of superficial bladder cancer. This local route of drug administration is now demonstrating promise in the treatment of interstitial cystitis/bladder pain syndrome (IC/BPS) with the benefit of minimal systemic side effects. Liposomes (LPs) are lipid vesicles composed of phospholipid bilayers surrounding an aqueous core. They can incorporate drug molecules, both hydrophobic and hydrophilic, and vastly improve cellular uptake of these drug molecules via endocytosis. Intravesical LPs have therapeutic effects on IC/BPS patients, mainly due to their ability to form a protective lipid film on the urothelial surface and repair the damaged urothelium. This review co UR - https://tau.amegroups.org/article/view/7245