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A new strategy for the treatment of sorafenib-refractory metastatic renal cell carcinoma in China: combination with intermittent chemotherapy

  
@article{TAU27724,
	author = {Zicheng Xu and Xiao Li and Feng Qi and Xin Hu and Yuxiao Zheng and Hongzhou Cai and Ting Xu and Bin Yu and Qing Zou},
	title = {A new strategy for the treatment of sorafenib-refractory metastatic renal cell carcinoma in China: combination with intermittent chemotherapy},
	journal = {Translational Andrology and Urology},
	volume = {8},
	number = {4},
	year = {2019},
	keywords = {},
	abstract = {Background: This study assesses the clinical safety and efficacy of Gemcitabine and S-1 combination chemotherapy in sorafenib-refractory metastatic renal cell carcinoma (RCC) patients. 
Methods: The baseline characteristics and survival outcomes of 19 patients suffering from metastatic and progressive sorafenib-refractory RCC were retrospectively collected and analyzed from January 2010 to April 2014. Patients were treated by combining Gemcitabine (1,000 mg/m2, day 1 and day 8 of every cycle of 21 days) and S-1 (40 mg/m2, twice a day for 14 days, followed by the rest period of 7 days), with a continual treatment of sorafenib 400 mg twice a day in a cycle of 28 days. 
Results: After combination chemotherapy, the disease control rate was 68.4%. Among them, 6 patients (31.6%) had progressive disease (PD), 5 patients (26.3%) had stable disease (SD) and 8 patients (42.1%) had partial response (PR). The median time to progression (TTP) was 6.3 months (range, 2.0–32.7 months), and the median overall survival (OS) was 19.7 months (range, 5.7–45.0 months). In the survival analysis, comparing PD group, disease control (PR + SD) group showed an obviously longer TTP (median TTP: 9.5 vs. 2.0 months, 95% CI, 7.7–11.3 months, P},
	issn = {2223-4691},	url = {http://tau.amegroups.com/article/view/27724}
}