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Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles

	author = {Gianmartin Cito and Maria Elisabetta Coccia and Rita Picone and Andrea Cocci and Giorgio Ivan Russo and Giulio Garaffa and Rossella Fucci and Francesco Bertocci and Elena Borrani and Valentina Basile and Elisabetta Micelli and Luciana Criscuoli and Sergio Serni and Marco Carini and Alessandro Natali},
	title = {Impact of advanced paternal age on the intracytoplasmic sperm injection (ICSI) outcomes in donor egg cycles},
	journal = {Translational Andrology and Urology},
	volume = {0},
	number = {0},
	year = {2019},
	keywords = {},
	abstract = {Background: The purpose of this study is to assess the impact of paternal age on the oocyte-donation outcomes in intracytoplasmic sperm injection (ICSI) cycles.
Methods: Two hundred and seventy-eight infertile couples were retrospectively involved. Inclusion criteria were: infertility from almost 1 year, normal or sub-fertile seminal parameters, overall oocyte survival rate greater than 85%. Baseline characteristics included male age, recipient age, male body mass index (BMI), smoking, drinking status. Main outcome measures: fertilization rate (FR), cleavage rate (CR), pregnancy rate (PR).
Results: Patients were categorized in group 1 ≤45, group 2 >45 years. A total of 1,724 frozen oocytes were included. After warming, 1,642 oocytes survived. Median overall oocyte survival rate was 100% [interquartile range (IQR), 85–100%]. Median male age was 44±5.60 years (IQR, 31–70 years). Median recipients age was 42±3.62 years (IQR, 29–50 years). Group 1 included 166 men, group 2 112 men. Two hundred and seventy-eight fresh ICSI cycle were performed. “Two-pronuclear” (2PN) FR was 72.6%±0.20%, CR 93.0%±0.16%, PR 39.6%. Miscarriage rate was 25.5%. Live birth rate per cycles was 29.5%. Comparison between group 1, group 2 and ICSI outcomes confirmed an association with FR, resulting 80.0% (IQR, 67.0–83.0%) and 67.0% (IQR, 50.0–80.0%), respectively (P<0.01). There were no significant differences between the two groups with respect to seminal parameters.
Conclusions: It would be recommended more emphasis on the advancing male age when counselling older couples who undergo egg donation program.},
	issn = {2223-4691},	url = {}