TY - JOUR AU - Culine, Stéphane AU - Allory, Yves AU - Pfister, Christian PY - 2018 TI - Refining the use of neoadjuvant chemotherapy in locally advanced bladder cancer: from conviction to optimization JF - Translational Andrology and Urology; Vol 7, No 4 (August 15, 2018): Translational Andrology and Urology (Male Genitourinary Reconstruction and Trauma) Y2 - 2018 KW - N2 - Radical cystectomy (RC) remains the standard of care as local treatment of muscle-invasive bladder cancer (MIBC). However, the cancer-specific survival is approximately 50%, depending on the presence of extravesical extension and lymph node metastases. In other words, nearly 50% of patients develop metastases within 2 years after RC, implying the presence of micro-metastases at the time of surgery. Neoadjuvant chemotherapy (NAC) has been shown to improve survival of patients and international guidelines recommend NAC based on the available level I evidence (1,2). UR - https://tau.amegroups.org/article/view/20173