TY - JOUR AU - Wu, Alex K. AU - Zhang, Xiaoyu AU - Wang, Jianwen AU - Ning, Hongxiu AU - Zaid, Uwais AU - Villalta, Jaqueline D. AU - Wang, Guifang AU - Banie, Lia AU - Lin, Guiting AU - Lue, Tom F. PY - 2018 TI - Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model JF - Translational Andrology and Urology; Vol 7, Supplement 1 (March 14, 2018): Translational Andrology and Urology<sup>1</sup> Y2 - 2018 KW - N2 - Background: To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress urinary incontinence (SUI) in a vaginal balloon dilation (VBD) rat model. Methods: Thirty Sprague-Dawley rats were randomly grouped into normal controls, VBD only, and VBD with Li-ESWT. Li-ESWT was administered twice per week for 3 weeks. Afterward, all 30 rats were assessed with functional and histological studies. To explore the acute effect of Li-ESWT, another 25 rats, given intraperitoneal 5-ethynyl-2-deoxyuridine (EdU) at birth, were treated with Li-ESWT followed by assessment of vascular endothelial growth factor (VEGF) expression and endogenous progenitor cells distribution at 24 hours or 1 week after the last Li-ESWT therapy. Additionally, rat myoblast L6 cells were used for myotube formation assay in vitro . Results: Functional analysis with leak-point pressure (LPP) testing showed that rats treated with Li- ESWT following VBD had significantly higher LPP relative to those receiving VBD only (44.8±3.2 versus 27.0±2.9 cmH2O, P In vitro , Li-ESWT promoted myotube formation from L6 cells. Conclusions: Li-ESWT ameliorated SUI by promoting angiogenesis, progenitor cell recruitment, and urethral sphincter regeneration in a rat model induced by VBD. Li-ESWT represents a potential novel noninvasive therapy for SUI. UR - https://tau.amegroups.org/article/view/18070