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Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model

  
@article{TAU18070,
	author = {Alex K. Wu and Xiaoyu Zhang and Jianwen Wang and Hongxiu Ning and Uwais Zaid and Jaqueline D. Villalta and Guifang Wang and Lia Banie and Guiting Lin and Tom F. Lue},
	title = {Treatment of stress urinary incontinence with low-intensity extracorporeal shock wave therapy in a vaginal balloon dilation induced rat model},
	journal = {Translational Andrology and Urology},
	volume = {7},
	number = {1},
	year = {2018},
	keywords = {},
	abstract = {Background: To investigate the outcomes and mechanisms of low-intensity extracorporeal shock wave therapy (Li-ESWT) on stress urinary incontinence (SUI) in a vaginal balloon dilation (VBD) rat model. 
Methods: Thirty Sprague-Dawley rats were randomly grouped into normal controls, VBD only, and VBD with Li-ESWT. Li-ESWT was administered twice per week for 3 weeks. Afterward, all 30 rats were assessed with functional and histological studies. To explore the acute effect of Li-ESWT, another 25 rats, given intraperitoneal 5-ethynyl-2-deoxyuridine (EdU) at birth, were treated with Li-ESWT followed by assessment of vascular endothelial growth factor (VEGF) expression and endogenous progenitor cells distribution at 24 hours or 1 week after the last Li-ESWT therapy. Additionally, rat myoblast L6 cells were used for myotube formation assay in vitro. 
Results: Functional analysis with leak-point pressure (LPP) testing showed that rats treated with Li- ESWT following VBD had significantly higher LPP relative to those receiving VBD only (44.8±3.2 versus 27.0±2.9 cmH2O, P},
	issn = {2223-4691},	url = {http://tau.amegroups.com/article/view/18070}
}