TY - JOUR AU - Chi, Thomas AU - Usawachintachit, Manint AU - Filippou, Pauline AU - Bayne, David AU - Hu, Weiguo AU - Chang, Helena AU - Xia, Lei AU - Chen, Qi AU - Xue, Wei AU - He, Hui AU - Long, Qingzhi AU - Arsovska, Olga AU - Taylor, Eric AU - Paterson, Ryan AU - Sur, Roger L. AU - Chew, Ben AU - Stoller, Marshall L. AU - Li, Jianxing PY - 2016 TI - Significant differences in struvite and cystine stone frequency seen among Chinese nephrolithiasis patients living in North America compared to those living in China JF - Translational Andrology and Urology; Vol 5, No 3 (June 01, 2016): Translational Andrology and Urology (Peyronie’s Disease) Y2 - 2016 KW - N2 - Background: Interracial disparities in nephrolithiasis prevalence have been reported, but the interplay between genetics and the environment for urinary stone disease risk factors is poorly understood. To examine how environment may alter genetic predisposition for stone formation, we established the International Chinese Consortium on Nephrolithiasis (ICCON) as a multi-institutional collaboration to examine patterns of nephrolithiasis presentation between Chinese patients living in different countries. Methods: Chinese patients undergoing percutaneous nephrolithotomy (PCNL) at six participating institutions in China and North America over 4 years were reviewed retrospectively. Patient demographics and clinical data were compared between Chinese patients living in China and North America. Results: A total of 806 patients were included, encompassing 721 Chinese patients living in China and 85 living in North America. Nephrolithiasis patients living in China were more likely to be male (67% vs . 56%, P=0.02), present at a younger age (48.6±15.0 vs . 55.0±13.0 years, P vs . 25.9±5.7, P=0.04) but were less likely to form struvite stones (5.5% vs . 14.1%, P Conclusions: Significant differences exist between Chinese nephrolithiasis patients living in China compared to those living in North America, highlighting the importance of environmental factors in addition to genetics in modulating risk for urinary stone disease. UR - https://tau.amegroups.org/article/view/10458