TY - JOUR AU - Al-Thakafi, Sultan AU - Al-Hathal, Naif PY - 2016 TI - Peyronie’s disease: a literature review on epidemiology, genetics, pathophysiology, diagnosis and work-up JF - Translational Andrology and Urology; Vol 5, No 3 (June 01, 2016): Translational Andrology and Urology (Peyronie’s Disease) Y2 - 2016 KW - N2 - Peyronie’s disease (PD), a fibromatous disorder of the tunica albuginea of the penile corpus cavernosum, named after the French physician Francois de la Peyronie, is characterized by pain, plaque formation, penile curvature, and plaque calcification. The epidemiological data on PD is inconsistent, with recent reports stating a prevalence of up to 9%, and the condition affecting men of all ages, from teenagers to septuagenarians. We are just beginning to elucidate the role of genetics as a causative factor for PD. Chromosomal abnormalities and single-nucleotide polymorphisms have been shown to be associated with fibrotic diatheses. Tunical mechanical stress and microvascular trauma are major contributory factors to the pathophysiology of PD. The diagnosis of PD can be made using a combination of clinical history, physical examination and, sometimes, imaging modalities. A better understanding of the molecular pathophysiology of this condition remains paramount for the development of newer and more effective disease-targeted interventions. UR - https://tau.amegroups.org/article/view/10408