Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for male fertility evaluation. While its detrimental implications on sperm function were extensively investigated, little is known about the actual indications for performing SDF analysis. SDF testing is recommended in patients with clinical varicocele and borderline to normal semen parameters as it can better select varicocelectomy candidates. High SDF is also linked with recurrent spontaneous abortion (RSA) and can influence outcomes of different assisted reproductive techniques.
Guest Editors (From top left to bottom right)
Ashok Agarwal, PhD, HCLD
Professor and Director, American Center for Reproductive Medicine, Cleveland Clinic, Mail Code X-11, 10681 Carnegie Avenue, Cleveland, USA
Ahmad Majzoub, MBChB, MD, CABU
Associate Consultant, Department of Urology at Hamad Medical Corporation, Doha, Qatar
Sandro Esteves, MD, MSc, PhD
ANDROFERT, Andrology and Human Reproduction Clinic, Referral Center for Male Reproduction, Campinas, SP, Brazil;
Chak-Lam Cho, FRCS (Urology) (Edin), FHKAM (Surgery), FCSHK (Urology)
Associate consultant, Department of Surgery of Kwong Wah Hospital in Hong Kong