AB064. Diagnostic ureteroscopy for upper tract urothelial carcinoma is independently associated with intravesical recurrence after radical nephroureterectomy
Poster Presentation

AB064. Diagnostic ureteroscopy for upper tract urothelial carcinoma is independently associated with intravesical recurrence after radical nephroureterectomy

Pei Liu, Xiao-Hong Su, Geng-Yan Xiong, Xue-Song Li, Li-Qun Zhou

Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China


Objective: To determine the effect of diagnostic ureteroscopy on intravesical recurrence in patients with upper tract urothelial carcinoma (UTUC) after radical nephroureterectomy (RNU).

Methods: We conducted a retrospective analysis of 664 patients who were treated with RNU for UTUC from June 2000 to December 2011, excluding those who had concomitant/prior bladder tumors. Of the 664 patients, 81 underwent diagnostic ureteroscopy (URS). We analyzed the impact of diagnostic ureteroscopy on intravesical recurrence (IVR) using the Kaplan-Meier method. Univariate and multivariate analyses were used to determine the independent risk factors.

Results: The median follow-up time was 48 months [interquartile range (IQR): 31–77 months]. Patients who underwent ureteroscopy were more likely to have a small (P<0.01), early-staged (P=0.019), multifocality (p=0.035) and ureteral tumor (P<0.001). IVR occurred in 223 patients during follow-up within a median of 17 months (IQR: 7–33). Patients without preoperative ureteroscopy have a statistically significant better 2-year [(79.3±0.02)% vs. (71.4±0.02)%, P<0.001] and 5-year intravesical recurrence-free survival rates [(64.9±0.05)% vs. (44.3±0.06)%, P<0.001] than patients who underwent ureteroscopy. In multivariate analysis, the diagnostic ureteroscopy (P=0.006), multiple tumors (P=0.001), tumor size <3 cm (P=0.008), low-grade (P=0.022) and pN0 stage tumor (P=0.045) were independent predictors of IVR.

Conclusions: Diagnostic ureteroscopy is independently associated with intravesical recurrence after radical nephroureterectomy.

Keywords: Upper tract urothelial carcinoma%; radical nephroureterectomy (RNU); intravesical recurrence (IVR)


doi: 10.21037/tau.2016.s064


Cite this abstract as: Liu P, Su XH, Xiong GY, Li XS, Zhou LQ. Diagnostic ureteroscopy for upper tract urothelial carcinoma is independently associated with intravesical recurrence after radical nephroureterectomy. Transl Androl Urol 2016;5(Suppl 1):AB064. doi: 10.21037/tau.2016.s064

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