Poster Presentation
AB063. Comparisons of prognosis between urothelial carcinoma of the upper urinary tract and bladder with pT3-4 diseases
Xiaohong Su1, Qi Tang1, Dong Fang1, Gengyan Xiong1, Qun He1, Lei Zhang1, Pei Liu1, Yu Fan1, Han Hao1, Xuesong Li1, Liqun Zhou1, Nirmish Singla2
1Department of Urology, Peking University First Hospital, Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China; 2Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX, USA
Objective: To compare the prognosis of locally advanced upper tract urothelial carcinoma (UTUC) and bladder cancer (BC) in patients treated with radical surgeries.
Methods: A retrospective analysis of the clinicopathological data of 228 consecutive UTUC patients and 174 BC patients treated by radical surgeries from 2000 to 2012 at a high-volume center in China was conducted. Kaplan-Meier method and Cox regression were used to compare overall survival (OS) and cancer-specific survival (CSS) and to find prognostic factors.
Results: BC were associated with male sex (P<0.001), high grade (P=0.002), multifocality (P<0.001), positive lymph node (P=0.002), no hydronephrosis (P<0.001) and open surgical approach (P<0.001). UTUC have statistically significant better 5-year CSS rate (61.0% vs. 49.8%, P=0.008) and OS rate (58.3% vs. 37.4%, P<0.001) than BC. Bladder tumor location [UTCU vs. BC: hazard ratio (HR) =0.703 and HR =0.462] and positive lymph node status (HR =1.919 and HR =1.667) were independent risk factors of cancer-specific death and overall mortality, respectively.
Conclusions: Our data suggest that locally invasive urothelial carcinomas (UC) behave differently in the upper and lower urinary tracts. UTUC has a better prognosis than BC when stage and grade are considered simultaneously and lymph node involvement has significant influences on clinical outcomes of urothelial carcinoma.
Keywords: Bladder cancer (BC); upper tract urothelial carcinoma (UTUC); radical cystectomy; radical nephroureterectomy; prognosis
doi: 10.21037/tau.2016.s063
Cite this abstract as: Su X, Tang Q, Fang D, Xiong G, He Q, Zhang L, Liu P, Fan Y, Hao H, Li X, Zhou L, Singla N. Comparisons of prognosis between urothelial carcinoma of the upper urinary tract and bladder with pT3-4 diseases. Transl Androl Urol 2016;5(Suppl 1):AB063. doi: 10.21037/tau.2016.s063
