AB077. Relationship of TPO-Ab and TSH with in vitro fertilization and embryo transfer

Objective: Study of thyroid peroxidase antibodies and thyroid stimulating effect on in vitro fertilization embryo transfer ending.

Methods: From March 2011 to October 2013 in the reproductive center in Qinghai Province People’s Hospital in vitro fertilization embryo transfer a total of 378 cycles were analyzed. (I) Basis for TPO-Ab grouping: research group is thyroid peroxidase antibody positive and thyroid function in patients with normal 69 cycles (TPO-Ab+ group), control group is thyroid peroxidase antibody negative and thyroid function in patients with normal 309 cycles (TPO-Ab− group). (II) Basis for TPO-Ab+ and TSH grouping: research group is thyroid peroxidase antibody positive and thyroid stimulating hormone <2.5 uiu/mL patients 31 cycles (TPO-Ab+ & TSH <2.5 group), control group is thyroid peroxidase antibody positive and thyroid stimulating hormone ≥2.5 uiu/mL patients 38 cycles (TPO-Ab+ & TSH ≥2.5 group). (III) Basis for TPO-Ab− and TSH grouping: research group is thyroid peroxidase antibody negative and thyroid stimulating hormone <2.5 uiu/mL patients 115 cycles (TPO-Ab− & TSH <2.5 group), control group is thyroid peroxidase antibody negative and thyroid stimulating hormone ≥2.5 uiu/mL patients 194 cycles (TPO-Ab− & TSH ≥2.5 group).

Results: (I) TPO-Ab group results: there was no statistical difference between research group and control group with the general information, super ovulation scheme, the number of eggs, super ovulation, portable intrauterine embryo number, embryo transfer number, transplantation days membrane thickness, TSH, T3, T4 and pregnancy rate. IVF fertility rate between the two groups is 79.76% and 79.76% respectively, high quality embryo rate (46.59%, 54.49%) TPO-Ab+ group was lower than that in group TPO-Ab−, the difference was statistically significant (P<0.05); abortion rate (33.33%) of TPO-Ab+ group was obviously higher than that of TPO-Ab− control group (16.11%), the difference was statistically significant (P<0.05). (II) TPO-Ab+ grouping and TSH results: there was no statistical difference between research group and control group with the general information, super ovulation scheme, the number of eggs, super ovulation, fertilization rate, portable embryo number, number of embryo transfer, transfer day intrauterine membrane thickness, T3, pregnancy rate, miscarriage rate, but the TPO-Ab+ & TSH <2.5 groups of abortion rate (18.75%) is lower than the TPO-Ab+ & TSH ≥2.5 group (47.06%), high quality embryo rate between the two groups (55.39%, 40.32%) TPO-Ab+ & TSH <2.5 groups significantly higher than the TPO-Ab+ & TSH ≥2.5 groups, the difference was statistically significant (P<0.05), T4 value between the two groups (15.76±2.00 mm, 14.27±2.04) TPO-Ab+ & TSH <2.5 group is significantly higher than the TPO-Ab+ & TSH ≥2.5 group, and the difference was statistically significant (P<0.05). (III) TPO-Ab− grouping and TSH results: there was no statistical difference between research group and control group with the general information, super ovulation scheme, the number of eggs, super ovulation, fertilization rate, portable embryos for several days, the number of embryos, the transplantation intrauterine membrane thickness, T3, T4, pregnancy rate, miscarriage rate. High quality embryo rate between the two groups (58.19%, 52.19%) TPO-Ab− & TSH <2.5 group is significantly higher than the TPO-Ab− & TSH ≥2.5 group, the difference was statistically significant (P<0.05).

Conclusions: Thyroid peroxidase antibody positive and high thyroid stimulating hormone have negative effects on IVF-ET ending, for TPO-Ab positive and TSH acuity 2.5 uiu/mL before receiving IVF-ET in patients with thyroid function should be adjusted to IVF-ET.

Keywords: TPO-Ab; TSH; in vitro fertilization embryo transfer; abortion; pregnancy