Article Abstract

Extension of the therapeutic spectrum in castration-resistant prostate cancer: Osteoclast inhibition with denosumab

Authors: Johannes M. Wolff, Hans-Peter Schmid


Denosumab is a human monoclonal antibody (IgG2) that binds to RANK ligand (RANKL). It reduces osteoclasts and thereby decreases bone resorption and cancer-induced bone destruction.


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