Introduction: Cross-linked dextran and polymethylmethacrylate
(PMMA) mixture (Lipen-10®) is a newly developed tissue filler
for soft tissue augmentation. The purpose of this study was to
evaluate efficacy and tolerability of cross-linked dextran and
PMMA mixture on penile enhancement.
Materials and Methods: A total 20 adult males who wanted
penile enhancement were enrolled at 2 centers. Mean patients
age were 44.4 years (20-70). Lipen-10® was injected into the
subcutaneous tissue of the penile shaft, between Dartos fascia
and Buck's fascia, using the fanning technique. The penile girth
and length were measured with a caliper in the flaccid state,
before and 3, 6 and 12 months after the injection. Any adverse
events were also recorded during the trial.
Results: Mean injected volume of Lipen-10® was 23.73
mL(range 17 to 30 mL). The circumference increased by 3.7 cm
(50.5 %, P<0.0001) at penile base, 4.2 cm (59.2 %, P<0.001)
at mid-shaft, and 3.8±1.0 cm (53.8 %, P<0.0001) at distal
shaft, and the length by 3.0 cm (83.3 %, P<0.001). There was
no significant difference in 3 circumferences between 6 and 12
months post-treatment (P-values of 0.796, 0.498, and 0.6 for
penile base, mid-shaft and distal shaft, respectively). A 5 mmsized
palpable nodule on penile shaft and a mild asymmetry
of penile shape were observed as complication. There were no
clinically significant adverse events in all subjects.
Conclusions: Penile injection of cross-linked dextran and
PMMA mixture led to a significant increase in penile size,
showed a good durability, and was well tolerated, without serious
adverse events. These results suggest that penile injection of
cross-linked dextran and PMMA mixture may be a new effective
method for penile enhancement.