Objective: To investigate the expressions of Heparanase-1
(HPA-1), vascular endothelial growth factor (VEGF) and
vascular endothelial growth factor receptor-2 (VEGFR-2) in
adrenocortical carcinoma (ACC) as well as the relationship of
HPA-1 and VEGF with microvessel density (MVD).
Methods: The expressions of HPA-1, VEGFR-2, VEGF and
MVD were detected by immunohistochemical staining in 20
cases with adrenocortical adenoma and 24 with adrenocortical
Results: HPA-1 staining was seen in 91.67% (22/24) of the
malignant cases versus 15.00% (3/20) of the benign, with
significant difference (P<0.01); VEGF expressed highly in
the ACC group (17/24, 70.83%) and lowly in the benign
group(5/20, 25.00%), with significant difference (PP<0.05);
A total of 19 of 24 (79.17%) malignant cases showed positive
staining for VEGFR-2 and 5 of 20 (25.00%) benign cases
showed positive, with significant difference (PP<0.05).
MVD in adrenocortical carcinoma was higher than those in
adrenocortical adenoma (84.70±12.44 vs. 21.05±8.07), with
significant difference (PP<0.05).
Conclusions: The high expression of HPA-1, VEGF and VEGFR-2
in ACC contribute to tumor angiogenesis, which provide the
theoretical evidence for anti-angiogenesis regime in ACC.