Objective: To investigate the efficacy and safety of sertraline
combined with stellate ganglion block (SGB) in treatment of
permature ejaculation (PE).
Methods: A total of 50 patients with PE were randomly enrolled
into 2 groups, each including 25 members. Over a 4-week
treatment period, the sertraline group took sertraline 50 mg once
a day; and the combined group (Sertraline with SGB) were given
both sertraline 50 mg once a day as well as SGB therapy tiwice
a week. All patients finished PE questionnairs which includes
4 items (perceived control over ejaculation, personal distress
related to ejaculation, satisfaction with sexual intercourse,
interpersonal difficulty related to ejaculation), and estimated
intravaginal ejaculation latency time (IELT) was recorded.
Results: After treatment, IELT increased for both group,from
baseline were (4.34±2.12) and (3.65±2.23) min in sertraline
group, (6.23±2.66) and (5.22±3.22) in combined group,
respectively. Moreover, the improvements of IELT and PRO
achieved were more satisfied in combined group than in
sertraline group. The differences were significant.
Conclusions: The combination of sertraline with SGB was more
effective in treatment of PE than sertraline monotherapy,which
indicated that the combined theropy may provide a new way for
treatment of PE.