Objective: Late onset hypogonadism (LOH) not only brings
bothersome symptoms and frustrations to patients, but also
negatively impact on men's psychological well-being. Studies
examining the interrelationship among symptoms of androgen
deficiency, psychological well-being and quality of life are
Methods: Eligible subjects were asked to complete the following questionnaires at baseline and month 6: AMS rating scale,
Hospital Anxiety and Depression Scale (HADS), Perceived
Stress Scale (PSS) and The Short Form Health Survey-12 (SF-
12). In this study, subjects were treated and monitored for 6
months with oral testosterone undecanoate (TU) capsules, each
containing 40 mg TU (Andriol). All the subjects were orally
administered 120-160 mg TU on a daily basis. T tests were used
to compare total and free T levels between baseline and month
6. ANOVA was used to compare the change from baseline.
Results: 80 eligible subjects were recruited and followed up.
Serum testosterone concentrations before and after intervention
were 230±21 ng/dL and 395±34 ng/dL. The mean HADS
anxiety subscale scores for the subjects at baseline and in month
6 were 3.47±0.4 and 1.72±0.2, respectively (t=1.526, P<0.05).
Additionally, the mean HADS depression subscale scores were
4.91±0.6 and 2.39±0.3, respectively (t=3.466, P<0.05). The
mean scores on the Perceived Stress Scale (PSS) for the subjects
at baseline and in month 6 were 12.88±2.1 and 9.83±1.7,
respectively (t=4.009, P<0.05). Significantly improved SF-
12 could be observed (t=1.433 and 1.118, respectively; both
Conclusion: Androgen replacement not only improves
androgen deficiency associated symptoms, but is also responsible
for comprehensive improvement in psychological issues.