Objective: To identify the role of seminal plasma alphaglycosidase
in the development, diagnosis and therapy of
infertility and to explore the relationship between seminal
plasma alpha-glycosidase and seminal parameters or biochemical
analysis in infertile men.
Methods: Semen samples were harvested from 616 infertile
men who were treated in our center from January 2009 to March
2011. Seminal plasma alpha-glycosidase's normal level was set
between 35.1-87.7 U/mL, lower than this level was considered as
abnormal. Seminal parameters and biochemistry were compared
between people with normal and abnormal alpha-glycosidase.
Results: Compare those with abnormal alpha-glycosidase,
patients with normal had signif icantly higher sperm
concentration, percentage of rapid progressive motility sperm,
sperm viability, curvilinear velocity, straight line velocity, and
lower seminal leucocyte and immotile sperm (all P<0.05).
Seminal plasma alpha-glycosidase had positive correlation with
sperm concentration, percentage of rapid progressive motility
sperm, sperm viability, curvilinear velocity, and straight line
velocity (all P<0.05), whereas it had negative correlation with
seminal leucocyte and immotile sperm. Seminal volume, pH, age
of patient, coliquation of semen, normal morphology percentage,
seminal elastase, zinc, fructose, and acid protease showed no
relationship with alpha-glycosidase's level (all P>0.05). The
level of alpha-glycosidase was significantly higher in patients
with nonobstructive azoospermia than in those with obstructive
Conclusions: Seminal alpha-glycosidase well reflects the
function of epididymis. Obstruction above the tail of epididymis
may elevated its level.