MR 16. Effectiveness of testosterone undecanoate treatment in men with asthenospermia
Male Reproduction

MR 16. Effectiveness of testosterone undecanoate treatment in men with asthenospermia

Bo Song, Zhimning Cai

Guangdong Key Lab. Male Reproductive Medicine & Genetics, Shenzhen Hospital, Peking University, China

Objective: To assess the effectiveness of testosterone undecanoate on sperm motility and pregnancy incidence in men with asthenospermia.

Design: Retrospective and clinical trial.

Participants: Fifty men with asthenospermia.

Interventions: Patients were randomized to rec

eive placebo, T undecanoate (80 mg per day).

Main outcome measures: Pregnancy incidence and sperm characteristics after 1, 2 and 3 months of medication and 3 months after the end of the trial.

Results: Compared with the placebo, T undecanoate treatment produced a satisfactory improvement of seminal motility (F=55.904, P=0.000). In the groups treated with T undecanoate, the incidence of pregnancy was 28.2% while the incidence of pregnancy of placebo groups was 11.1%. In active treatment groups, twenty six people took T undecanoate for more than 3 months. In the 3 months, semen volume showed no statistical difference (F=1.206, P=0.312) before and after treatment, sperm concentration and motility showed statistical difference. Motility grade a showed significantly higher increment in 2 and 3 months after treatment than 1 month and there was no statistical difference between 2 and 3 months. So did grade b.

Conclusions: The results indicate that T undecanoate decreases sperm concentration and increases seminal motility, leading to a higher incidence of pregnancy in couples with infertility related to asthenoaspermia.

Key words

Testosterone undecanoate; sperm; motility; asthenospermia

DOI: 10.3978/j.issn.2223-4683.2012.s109

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