Objective: Aim of this study for evaluate the efficacy of the combined
therapy of tadalafil and testosterone replacement therapy
in management of diabetic erectile dysfunction (DMED) combined
Subjects and Methods: Forty-three patients of DMED with hypogonadism
were reviewed and the combined therapy of tadalafil
and testosterone replacement therapy were evaluated. According
to the penentration insertion condition, the patients were
divided into 2 groups: insertion-able (A group), un-insertion (B group). All of patients oral administration testosterone undecanoate
(120 mg/d) and on demanded Tadalafil (10 mg) twice a
week for group A and Tadalafil (20 mg) twice a week for group B,
and the treatment period was 3 months. as a control group (C),
thirty patients with DMED (average 45.61 years old) were treated
only Tadalafil (10 mg) twice a week.The serum testosterone
level, IIEF-5 score and Padam score were used for evaluation the
clinical efficacious.All the patients had the desire to improve the
sexual life. This group was aged 32-57 years old (average 46.35
years old), course of disease was above 2 years, blood sugar was
well controlled, testosterone level was under 3 ng/mL. Treatment
approach as below: and regularity sex life in therapeutic session.
Reuse the IIEF-5 score and Padam score and recheck the testosterone
level after treatment. testosterone level was 2.87±0.54
ng/mL (normal control: 5.23±2.42 ng/mL, consult scope: 2-10
ng/mL) before therapy.
Results: The average score of the IIEF-5 was 18.25±7.38 after
therapy, it was significantly higher (P<0.01) than that of
12.36±5.73 before therapy. The average score of the Padam score
was 31.73±4.36 before therapy, compared with 18.41±2.75 after
therapy, the score was obviously descent, the difference had statistics
significance (P<0.01). Compared with control group C,
the score of the IIEF-5 and the Padam score were significantly affected
(P<0.01) in group A and B after therapy, The average level
of testosterone was 3.26±0.62 ng/mL after therapy, it was no statistics
significance (P>0.05) compared with that before therapy.
The sex life of 38 pts were improved obviously. 26 pts of A group
had got better sex life, among 17 pts of B group pts, 12 pts could
insert, the sex life obviously improved, but for the rest 5 pts still
remained un-insert, they would need further therapy.
Conclusions: The combination treatment with twice a week
dosage of tadalafil and testosterone replacement therapy is a new
effective way for the treatment of DMED.