Introduction: The importance of endothelial dysfunction
and inflammation in erectile dysfunction (ED) has been well documented and it may share its pathogenesis with
atherosclerotic vascular disease. The serum C-reactive protein
(CRP) is a non-specific marker of systemic inflammation, and
well established risk factor in atherosclerotic vascular disease.
Recently introduced high sensitive CRP (hsCRP) has more
accurate value than conventional CRP. Hence, we evaluated the
association between hsCRP and ED in aging men.
Material and Methods: Our study used a multistage stratified
design to recruit a random sample of 1510 men aged 45 years
or older in Chuncheon, Korea. Men with the urologic (except
for BPH) or neurologic diseases that could cause erectile
dysfunction were excluded. Also, if men had been recently
medical conditions that could cause or suppress inflammation
such as infection or NSAID use, these men were excluded. The
serum hsCRP levels were analyzed by continuous variable, top
10 percentile, top 20 percentile and top 25 percentile. ED was
defined as an International Index of Erectile Function-5 (IIEF-5),
analyzed by severe (5-7 points), moderate (8-11 points), mild
(12-21 points), and normal (>21 points).
Results: Finally 338 men were recruited. Mean age was 69.1
(47-93) years, and mean serum hsCRP was 0.277 (0.035-
7.769) mg/L. Men with mild, moderate, and severe ED were
100 (30.1%), 16 (4.8%) and 110 (33.1%), respectively. No
statistically significant association was observed between the
hsCRP levels and IIEF-5 (P>0.05). Also, in analyses including
covariates such as age, body mass index, hypertension, diabetes
mellitus, hyperlipidemia, alcohol, smoking and IPSS index, the
serum hsCRP level was not significant risk factor.
Conclusions: Age, alcohol and IPSS were associated with
ED in aging men. However, the serum hsCRP levels were not
associated with ED in aging men. The systemic inflammation is
not a immediate risk factor of ED in aging men.