Purpose: To discuss the pathological and clinical characteristics,
treatments and prognosis of chromophobe renal cell carcinoma (CRCC).
Methods: We developed a database that contained 1,870
patients who were diagnosed with renal cell carcinoma (RCC)
and who underwent surgery in our hospital between 2002 and
2010. Afterward, the clinical and pathological data of 53 CRCC
cases were extracted and analyzed.
Results: The mean age of the 53 patients at diagnosis was 50.2
years (range, 21-88 years), and the ratio of male to female was
1:1. All tumors were unilateral and a majority of them (69.8%)
were discovered incidentally. The mean tumor size was 5.8±3.2
cm (range 2-20 cm). Stage T1, T2, and T3 tumors, in accordance
with 2004 TNM classification, accounted for 75.5, 13.2 and
11.3% of all cases, respectively. By histologic grading, 11.3, 73.6
and 15.1% of the tumors were G1, G2, and G3, respectively.
Forty-one (77.4%) patients underwent radical nephrectomy,
12 (22.6%) underwent partial nephrectomy. Forty-five (84.9%)
patients with follow-up results were alive after a mean followup
of 34 months (range, 4-79 months). Tumor metastasis was
discovered in 2 patients: one tumor metastasis was found in the
liver 4 months postoperation, and the other was found in the
lumbar vertebrae 47 months postoperation. No local recurrence
was found. The overall survival rate was 100%.
Conclusions: CRCC is an uncommon subtype of RCC, with a
favorable prognosis. Chinese patients are seemingly younger at
diagnosis. Prediction of prognosis is still difficult.