Purpose: To evaluate the prevalence of baseline chronic kidney
disease (CKD) in upper urinary tract urothelial carcinoma
(UTUC) patients attending to Peking University First Hospital
Urology Department from 2002 to 2010. To explore how
much CKD patients had been ignored using the sCr as the only
criteria to judge renal function in UTUC population.
Materials and Methods: Using the database of our hospital,
we searched out and finally identified definitely pathologically
diagnosed UTUC patients from 2002-2010. eGFR (estimated
glomerular filtration rate) was calculated by Modification of
Diet in Renal Disease (MDRD) formulas modified based on
Chinese population. CKD stages were defined by the definitions
of American National Kidney Foundation.
Results: 723 of 828 patients had appropriate record to calculate
the Egfr (mL/min). Approximate 60% of all patients had CKD
III+: 315 patients (44.57%) had CKD III, 55 patients (7.61%)
had CKD IV, and 60 patients (8.30%) had CKD V. 492 of 723
patients (68.05%) had a normal sCr ≤1.4 mg/dL, in which,
199 patients (40.45%) had CKD stage III+. In the >70 years
cohort, the same two ratios are 64.04% (180/281) and 54.44%
Conclusions: More than half of all the UTUC
patients have CKD stage III or higher, in the >70 years group,
the ratio is greater (P<0.01). Use sCr to evaluate the renal
function will ignore large proportion of patients suffering from
CKD stage III+, especially in the over 70 years group (P<0.01).
Compare with the western population, in our center, the
prevalence of UTUC is lower in Chinese men compared with
Chinese women (P<0.01).