Article Abstract

The role of adipose stroma in prostate cancer aggressiveness

Authors: Mikhail G. Kolonin, John DiGiovanni

Abstract

Resistance of prostate cancer to treatment remains a challenge. Surgery, chemotherapy, and androgen deprivation therapy cure most patients with early-stage disease. However, metabolic reprogramming, androgen receptor bypass, and sustained immunotolerance results in treatment-refractory prostate cancer that progresses to metastatic and lethal stages.