Article Abstract

Dysregulated metabolism: a relevant player in prostate cancer progression and clinical management

Authors: Matteo Ferro, Carlo Buonerba, Giuseppe Di Lorenzo, Ottavio de Cobelli, Daniela Terracciano


It is well accepted that cancer cells have different metabolic programme compared to normal cells (1). Rapidly replicating tumor cells requirements to support inappropriate cell proliferation and maintain growth is reflected at least in part by a metabolic shift towards aerobic glycolysis, a phenomenon known as Warburg effect and a modification in gene expression for enzymes involved in other pathways supporting proliferation (2,3). Increased glucose uptake lead to modifications of many metabolites mainly associated with cell growth and stress (4,5).