The study investigated the effect of microsurgical subinguinal
varicocelectomy in male infertility.
A prospective study was conducted at the Andorlogy center of
Peking University First Hospital from January 2009 to February
2011. Married men 20-46 year of age who had experience
infertility ≥1 year, had palpable varicoceles, and with at least one
impaired semen parameter (sperm concentration <20 million/
ml, progressive motility <50%, or normal morphology <30%)
were eligible. Exclusions included subclinical or recurrent
varicoceles, normal semen parameters, and azoospermia. All
the patients were performed with subinguinal microsurgical
varicocelectomy. Semen analyses were obtained at baseline
(three analyses) and at follow-up months 3, 6, 9, and 12. The
mean of each sperm parameter at baseline and follow-ups was
determined. Testosterone and inhibin were measured before and
12 months after the operation. We measured the spontaneous
pregnancy rate, changes from baseline in mean semen
parameters, changes from baseline in testosterone and inhibin,
and the occurrence of adverse events during 12-months followup.
Paired t-test was used to test the differences pre- and postthe
operation, when P<0.05 was considered significant.
127 patients were enrolled into the study and the mean age was
28.6±7.3 years. Spontaneous pregnancy was achieved in 40.16%.
The mean of all semen parameters, testosterone and inhibin
improved significantly in follow-up versus baseline (P<0.05). No
adverse events were reported after the operation 12 months later.
Our result provided the effect of varicocelectomy over
observation in infertile men with palpable varicoceles and
impaired semen quality, with increased spontaneous pregnancy
rate and improvements in semen characteristics, testosterone
and inhibin within 12 months of follow-up.