AB086. Effects of testosterone replacement therapy on quality of life in patients with chronic kidney disease
Printed Abstract

AB086. Effects of testosterone replacement therapy on quality of life in patients with chronic kidney disease

Min Gu Park1, Jeong Woo Lee2, Jeong Kyun Yeo1

1Department of Urology, College of Medicine, Inje University, Seoul, Korea; 2Department of Urology, College of Medicine, Dongguk University, Ilsan, Korea


Background: We investigated the effect of testosterone replacement therapy (TRT) on the quality of life (QoL) of patients with chronic kidney disease (CKD) and tried to confirm the safety of TRT.

Methods: Forty male patients with grade III–IV CKD whose serum testosterone level is less than 350 ng/dL were consecutively enrolled in this study. The patients were randomly divided into two groups: group 1 patients were recommended to exercise and group 2 patients were treated with testosterone gel for 3. Before and after treatment, body mass index (BMI), vital sign, and hand grip strength was checked and serological tests and self-questionnaire such as SF-36, AMS, and IPSS were performed.

Results: Compared to baseline, there was no significant difference in serum testosterone levels, scores of SF-36, AMS and IPSS, and grip strength in group 1 after 3 months. In group 2, significant increase in testosterone, Hb, and Hct were found, and the grip strength was significantly increased after TRT. Significant improvement in scores of SF-36, AMS, and IPSS was also confirmed after TRT. There was a significant difference in testosterone, Hb, Hct, grip strength, and scores of SF-36, AMS, and IPSS between the two groups after 3 months. In group 2, there was no statistically significant change in glomerular filtration rate after TRT. All patients in group 2 were satisfied and wanted to continue TRT.

Conclusions: TRT improves QoL as well as testosterone deficiency (TD) symptoms in the patients with moderate to severe CKD safely, and is expected to have a good effect on the improvement of anemia, which is common situation in CKD.

Keywords: Hypogonadism; testosterone; chronic kidney disease (CKD); quality of life (QoL)


doi: 10.21037/tau.2018.AB086


Cite this article as: Park MG, Lee JW, Yeo JK. Effects of testosterone replacement therapy on quality of life in patients with chronic kidney disease. Transl Androl Urol 2018;7(Suppl 5):AB086. doi: 10.21037/tau.2018.AB086