AB017. Experimental study of pulsed ultrasound in the treatment of stress urinary incontinence
Podium Lecture

AB017. Experimental study of pulsed ultrasound in the treatment of stress urinary incontinence

Huixi Li

Department of Urology, Andrology center of Peking University First Hospital, Beijing 100009, China


Abstract: Low intensity pulsed ultrasound (LIPUS) has shown its ability of restoring soft tissue injury in a number of studies, but little is known about its molecular mechanism. Recent studies reported the regulatory effect of LIPUS on stem cell activation. We investigated the possible therapeutic effect of LIPUS in a stress urinary incontinence (SUI) rat model and its influence on myogenic satellite cells. Fifty Sprague Dawley rats underwent vaginal distension and bilateral ovariectomy mimicking partum injury and menopause to construct SUI models, which were further randomized into 100 mW/cm2 LIPUS, 200mW/cm2 LIPUS, 300 mW/cm2 LIPUS and none-treatment control subgroups with ten rats per subgroup. Ten rats served as mock operation control. Here we found the leak point pressure and bladder capacity were restored in 200mW/cm2 LIPUS and 300 mW/cm2 LIPUS groups, but not in 100 mW/cm2 LIPUS group. More robust striated muscle regeneration was observed in 200mW/cm2 LIPUS group comparing with the SUI none-treatment group. Moreover, we found LIPUS activated the myodifferentiation of muscle satellite cells, which is correlated to p38 phosphorylation level. These results show LIPUS ameliorate the symptom of SUI and activate satellite cell myodifferentiation.

Keywords: Low intensity pulsed ultrasound (LIPUS); stress urinary incontinence (SUI); stem cell activation


doi: 10.21037/tau.2018.AB017


Cite this article as: Li H. Experimental study of pulsed ultrasound in the treatment of stress urinary incontinence. Transl Androl Urol 2018;7(Suppl 5):AB017. doi: 10.21037/tau.2018.AB017