A novel bladder cancer urinary biomarker: can it go where no marker has gone before?

Ryan W. Dobbs, Michael R. Abern


In their recent publication in BJUI, Pichler et al. (1) report the diagnostic accuracy of Xpert BC Monitor, a biomarker combining the measured expression of 5 mRNAs (ABL1, CRH, IGF2, UPK1B & ANXA10) in voided urine. The study evaluated the diagnostic accuracy of the assay in 140 patients with a known history of NMIBC. White light cystoscopy and urine cytology were the diagnostic gold standard. Within this cohort, 43 patients (30.7%) were found to have a tumor recurrence.