Peyronie’s disease: current therapy

Clay M. Pendleton, Run Wang


Peyronie’s disease is a connective tissue disorder affecting the tunica albuginea of the penis, causing a myriad of problems including penile pain, erectile dysfunction, penile deformity, and difficulty in performing coitus. Francois de la Peyronie first described this in 1743 while he was the surgeon for Louis XIV of France. Although the exact prevalence is unknown, it is relatively common with varying data quoting a prevalence of about 3.2-8.9% with more than 75% of cases occurring in men between 45 and 65 years of age. The incidence of PD following radical prostatectomy is reported to be as high as 15.9% and a recent study showed that penile curvature is a common finding (38.6%) at IPP implantation surgery for ED after prostate cancer treatment (1).