AdVance male sling
Review Article

AdVance male sling

Amanda S. J. Chung, Oscar A. Suarez, Kurt A. McCammon

Eastern Virginia Medical School, Norfolk, VA, USA

Contributions: (I) Conception and design: All authors; (II) Administrative support: KA McCammon, AS Chung; (III) Provision of study material or patients: All authors; (IV) Collection and assembly of data: All authors; (V) Data analysis and interpretation: All authors; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

Correspondence to: Kurt A. McCammon. Eastern Virginia Medical School, Norfolk, VA, USA. Email: MccammKA@evms.edu.

Abstract: The AdVance sling (American Medical Systems, Minnetonka, MN, United States of America) is a synthetic transobturator sling, which is a safe and effective minimally invasive treatment for mild to moderate stress urinary incontinence (SUI) in male patients. This article provides a step-by-step description of our technique for placement of the AdVance male sling, including details and nuances gained from surgical experience, advice for avoidance of complications and discussion on management of complications and sling failures. Patient selection is very important, including exclusion and preoperative treatment of urethral stenosis and bladder dysfunction. Previous pelvic radiation is a poor prognostic factor. In brief, the steps of sling placement are: (I) mobilization of the corpus spongiosum (CS); (II) marking and mobilization of the central tendon; (III) passage of the helical trocar needles exiting at the apex of the angle between the CS and inferior pubic ramus; (IV) fixation of the broad part of the sling body to the CS at the previous mark; (V) cystoscopy during sling tensioning; (VI) placement of a Foley urethral catheter; (VII) Subcutaneous tunnelling of the sling arms back toward the midline; (VIII) wound closure. The most common early postoperative complication is urinary retention but long-term retention is extremely rare. Management of sling failures include placement of an artificial urinary sphincter, repeat AdVance sling, urethral bulking agent or ProACT device.

Keywords: Urinary incontinence; suburethral slings; intraoperative complications; postoperative complications; urinary retention


Submitted Jul 18, 2017. Accepted for publication Jul 21, 2017.

doi: 10.21037/tau.2017.07.29


Introduction

The AdVance male sling (American Medical Systems, Minnetonka, MN, United States of America) is a synthetic transobturator sling, which is placed in a minimally invasive fashion, for the treatment of male stress urinary incontinence (SUI). It was developed by Rehder and Gozzi as a minimally invasive alternative to the Artificial Urinary Sphincter (AUS) (American Medical Systems, Minnetonka, MN, United States of America) (1). In short, sling placement involves the following steps: (I) corpus spongiosal dissection and mobilization; (II) identification and dissection of central tendon; (III) placement of needle passers through the obturator foramen; (IV) mesh placement at central tendon; (V) mesh tensioning and fixation with cystoscopy; (VI) incision closure (2).

In placing the sling, it is not only interesting but also useful to consider how the sling works: the AdVance transobturator sling contributes to male continence in several ways. When the sling is appropriately tensioned, the urethral bulb relocates a distance of 2–4 cm proximally into the pelvis. Supporting the bulb may indirectly facilitate continence in patients with post-prostatectomy incontinence (PPI) (3). The sling also provides support to the dorsal distal portion of the membranous urethra, which acts as a backstop during stress. In contrast to other slings, all this is achieved without causing any urethral obstruction (4). Rather, a mechanism of “dynamic compression” has been observed on ultrasound study (5).

In this article, we provide a step-by-step description of our technique for placement of the AdVance male sling, including details and nuances gained from surgical experience, advice for avoidance of potential surgical complications and management of complications if they occur.


Patient selection

Patient selection is very important: the AdVance sling is best suited for men with mild to moderate SUI (6). The AdVance sling has demonstrated safety and efficacy in the treatment of PPI, and can also be used in the treatment of male SUI due to other causes such as after transurethral resection of the prostate (TURP) and in men with neurogenic lower urinary tract dysfunction (NLUTD) (7-13).

It is our practice to evaluate every patient after open prostatectomy with cystourethroscopy to rule out vesicourethral anastomotic stenosis (VUAS), urethral stenoses or strictures (US), prior to placement of an AdVance sling. If urethral stricture or stenosis is present, we advise treating and stabilizing this for 3–6 months before sling placement. Typically, the patient is re-scoped 3–6 months’ after correction of VAUS or US and if the urethra remains patent, we proceed to sling insertion.

Urodynamic testing may also have a role in the evaluation of the patient with PPI (14,15). Among patients with lower urinary tract symptoms (LUTS) after radical prostatectomy (RP), 27% had detrusor overactivity (DO), 41% had detrusor underactivity (DU), and 17% had bladder outlet obstruction (BOO) (14). Patients with mixed urinary incontinence may be improved with anticholinergic, beta-3 adrenergic medication or other OAB therapy, prior to embarking on invasive surgical intervention for the stress component of their urinary incontinence. In some cases, adequate control of DO may move patients from severe range PPI to mild to moderate range PPI, and appropriate choice of continence device may be able to move from AUS to AdVance sling. DO is a negative prognostic factor for success (5,8); the presence of DU may increase the risk of urinary retention after sling insertion (16). Patients who void with Valsalva have a higher risk of loosening the sling postoperatively. Therefore, urodynamic evaluation may be beneficial for diagnostic and prognostic counselling, even if the results do not change choice of SUI procedure.

Patients with history of pelvic radiation are not good candidates for an AdVance sling. Although it is technically feasible to place a sling, we advise such patients to consider other treatment options (such as AUS). If they choose an AdVance sling, they can expect worse outcomes compared with patients who have not had any pelvic radiation (5,17-19). Radiation may limit urethral mobility and adequate proximal urethral relocation (15). It may also inhibit tissue healing and mesh ingrowth.

Men with NLUTD may be candidates for AdVance sling placement with satisfactory results (11,20,21). Evaluation and treatment of DO and low compliance should be completed prior to sling placement. Patients may have difficulty performing clean intermittent catheterization after sling placement, but changing catheter type usually overcomes this problem. Men with NLUTD and a sling in place must be committed to regular surveillance for risk of upper-tract deterioration.


Surgical technique

We perform an AdVance sling procedure with the patient under general anesthesia using laryngeal mask anesthesia—it can also be performed under spinal anesthesia. It is also important that the patient is extubated smoothly, with coughing avoided so as not to risk loosening the sling.

With the patient positioned in dorsal lithotomy, knees approximately shoulder-width apart and flexed no more than 90 degrees, a standard surgical prep is performed and the patient draped. A 5 cm midline perineal incision is made. The bulbospongiosus muscle is divided in its midline to expose the corpus spongiosum (CS). The CS is then mobilized distally, laterally, and proximally to the level of the central tendon. The CS at the level of the central tendon is marked either with an absorbable suture (4-0 Vicryl) or a marking pen before the central tendon is dissected off the CS (Figure 1A,B). Central tendon dissection allows for increased CS mobility during tensioning. Key points of surgical technique and further details of nuances are presented in Table 1.

Figure 1 (A,B) The corpus spongiosum at the level of the central tendon is marked with either an absorbable suture or marking pen before the central tendon is dissected off the corpus spongiosum.
Table 1
Table 1 Key points of surgical technique and details of nuances for AdVance sling placement
Full table

Next, bilateral stab incisions are made with a scalpel at a site 1–2 cm below the level of the adductor longus tendon just lateral to the ischiopubic ramus. This site is usually easily palpable as a ‘soft spot’, a spinal needle may be used to help identify the area of insertion. These small incisions will be sites of AdVance helical trocar entry. The trocar handle is held at a 45-degree angle, with the point of the trocar needle perpendicular to the patient’s skin, and placed straight through the small incisions (Figure 2). A finger from the surgeon’s contralateral hand is placed in the perineal incision below the ischiopubic ramus to protect the CS and guide needle placement. Two “pops” are felt; after the second “pop” the needle is turned approximately a quarter turn. The needle is palpable on the surgeon’s finger behind the ischiopubic ramus. Prior to bringing the trocar needle through the fascia, the surgeon’s ipsilateral hand is dropped, and the needle is brought out as high as possible in the apex formed by the ischiopubic ramus and CS (Figure 3). The mesh is secured to the needle and brought back through the stab incision. The trocar needle pass is repeated on the opposite side of the patient. Then, the central portion of the mesh is fixed to the CS with the proximal edge of the mesh being fixed at the level of our previous mark where the central tendon had been taken down. If this marking was lost accidentally, we can place a urethral catheter to locate the site where it makes a turn into the proximal bulbar urethra—this is a safe site to place the proximal aspect of the mesh. Two absorbable sutures (4-0 Vicryl or PDS) are placed proximally and two distally to secure the mesh to the CS (Figure 4).

Figure 2 The trocar handle is held at a 45-degree angle, the trocar needle point is oriented perpendicular to the patient’s skin, and surgeon’s contralateral hand is suitably positioned for safe trocar insertion.
Figure 3 After the two “pops” are felt, the trocar is turned and the ipsilateral hand of the surgeon is dropped so that the point of the trocar needle is brought out as high as possible in the angle formed by the ischiopubic ramus and corpus spongiosum.
Figure 4 Sutures are used to fix the central portion of the mesh to the corpus spongiosum with the proximal edge of the mesh being fixed at the level of our previous marking where the central tendon had been dissected off the corpus spongiosum.

The sling is tensioned by pulling firmly on the sling arms (Figure 5). Cystourethroscopy is performed during tensioning to confirm coaptation of the external sphincter and to rule out urethral injury. If no coaptation is seen, it is usually because the sling was placed too proximal. Therefore, the four sutures are removed and the sling repositioned approximately 0.5–1 cm distally. A 14 Fr. Foley urethral catheter is inserted to remain in place overnight. The outer coverings of the mesh arms are removed, and although the sling is self-anchoring, the mesh is tunneled back subcutaneously to the midline perineal incision with the aid of a tonsil clamp to reduce the risk of slippage of the mesh. Some surgeons have proposed securing both ends of the sling together with a suture, or making a second incision beneath the first one to anchor the ends of the sling subcutaneously at a 90° angle (22). Finally, the bulbospongiosus muscle is reapproximated, and the subcutaneous tissues and perineal incision closed. The bilateral trocar incisions are closed with a simple interrupted suture.

Figure 5 Pulling firmly on the sling arms tensions the sling.

Post-operative care

It is our practice to have patients stay in hospital overnight with a Foley urethral catheter on gravity drainage. The following morning, a void trial is conducted prior to the patient being discharged home. If the patient develops urinary retention, a 12 or 14 Fr. Foley urethral catheter is reinserted and the patient is discharged home with it attached to a leg bag. Rarely, the catheter may need to be introduced over a wire with the assistance of a cystoscope. Repeat void trial is performed at 5–7 days; if urinary retention lasts longer, subsequent void trials are performed at weekly intervals. Able patients may commence clean intermittent catheterization until adequate spontaneous bladder emptying is achieved. Risk of long term urinary retention is small. In a rare patient with retention lasting longer than 3 months, the sling may be surgically excised with the patient returning to his previous status.

Most patients experience minimal postoperative pain and may want to return to normal activity as soon as possible. However, it is imperative that the patient follows the postoperative instructions: avoid physical exertion, do not lift more than 15 lbs., do not squat or climb, for at least 6 weeks postoperatively. Patients who do not follow these instructions are at high risk of loosening their sling with return of incontinence. Patients with NLUTD and impaired mobility must be cautious not physically exert themselves during transfers.

For patients who report having done something in the first 6 weeks after sling placement which may have loosened the sling, a repeat sling placement may be performed. In these patients, re-exploration through the previous incision is performed, CS identified and dissection continued proximally until the edge of the mesh is palpable. The mesh arms are identified laterally with a right-angle clamp and transected, allowing the bulb of the CS to be pulled toward the surgeon. The broad portion of the mesh, which was attached to the CS is then excised. Another sling is then placed in correct position as described in the ‘Surgical Technique’ section of this article.


Complications

The overall complication rate for the AdVance sling was 12.3% in a systematic review (12). Severe complications, both intraoperative and postoperative, are rare (12,23). The main potential intraoperative complication is urethral injury during trocar passage. We have seen this in only two patients early in our experience.

Urinary retention is the most common early post-operative complication, occurring in 12–46% of patients; the risk of prolonged urinary retention is very low (23-25). Patients who experienced postoperative urinary retention had good continence outcomes (25). One sling was transected (0.4%) due to slippage of the sling with obstruction of the urethra (23). Other early postoperative complications include local wound infection (0.4%), febrile urinary tract infection (0.4%), persistent moderate perineal pain (0.4%) (23). There has been a case report of bleeding with hematoma, requiring blood transfusion in a patient who received early re-anticoagulation (26). There has been one case report of urethral mesh erosion in a patient with prior radiation (27). Sling explantation is also extremely rare (0.9%); in one study, an explantation was due to initial wrong placement and another due to symphysitis attributed to a Guillain-Barre Syndrome (not sling infection) (23).


Management of incontinence after AdVance sling

The failure rate after AdVance sling is 20% to 45.5% (28). In addition to evaluating the degree of further incontinence and its impact on quality of life, it is also important to differentiate between persistent incontinence and recurrent incontinence. Persistent incontinence suggests ongoing SUI (intrinsic sphincter deficiency), whereas recurrent incontinence may represent other pathology such as DO unless the patient gives clear history of having done something in the early postoperative period which may have loosened the sling. Reoperation on the outlet is only indicated in cases of ongoing SUI.

Insertion of an AUS is the ‘gold standard’ treatment after failed AdVance sling. The AdVance sling can be left in place during the salvage AUS procedure. It has been reported that up to 13% of men ultimately proceed to AUS implantation after sling surgery (29). AUS placement in this situation has a success rate of 80–90% (30). A comparison of outcomes in a group of patients who received AdVance sling then salvage AUS versus a group of patients who received virgin AUS procedures, showed that patients with salvage AUS compared favorably in terms of success and required revisions (30).

We have also performed repeat AdVance sling placement with encouraging results especially in cases of late failure (31). Success rate was 72% at 6 months and 56% at mean 17.5 months follow-up. Complication rates were low. Patients who failed late (>6 months) after their primary sling had better outcomes with salvage sling placement compared to patients who failed earlier after their primary sling (75% vs. 30%, P<0.05). This may be because patients who failed late were probably initially better candidates for sling placement than their counterparts. We believe it is also a reasonable option to offer a repeat AdVance sling placement to patients who give clear history of having initial continence success then having done something in the early postoperative period which may have loosened their sling with subsequent recurrence of incontinence.

Placement of a second AdVance sling is done in a similar manner to an initial sling placement with only several nuances in technique. We have found it slightly easier to begin the dissection further distal on the CS in a virgin plane. We mobilize the CS a little more than usual. Once the distal aspect of the sling is identified, we are able to place a right-angle clamp around the sling arms and transect them, allowing the CS to move toward the surgeon. We then excise the previous sling off the CS (Figure 6). This is usually difficult and we occasionally inadvertently enter the CS but have not injured the urethra during the dissection. Any CS openings are closed with an absorbable suture. The trocar needles are passed as previously described and the sling is placed usually slightly distal to the first sling.

Figure 6 The previous AdVance sling is dissected off the corpus spongiosum after the sling arms have been transected lateral to the corpus spongiosum which allows the corpus spongiosum to move toward the surgeon.

Soljanik et al. reported outcomes after repeat AdVance sling whereby the first sling was left in place and did not prohibit the placement of the second sling. At mean 16.6 months follow-up, 34.5% men required no pads, 37.9% had one dry “security” pad, 3.4% one wet pad, 3.4% two pads, 10.3% pad reduction ≥50%, and 10.4% treatment failure (28).

Mild persistent incontinence after AdVance sling may also be managed with injection of urethral bulking agents, such as Macroplastique (Uroplasty, Inc., Minnetonka, MN, USA), at the area of coaptation with relatively good results.

Another option to consider would be insertion of ProACTTM balloons (Uromedica, Inc., Plymouth, MN, USA). Al-Najar et al. used the ProACTTM system in ten patients with persistent incontinence after their sling. At mean 6 months follow-up, all ten patients were pad free (32). The ProACT is not currently available in the United States of America.


AdVance XP

Since 2010, the second generation of the AdVance sling, the AdVance XP, has become available in several countries (not currently approved by the FDA in the US). It has: updated mesh waves with integrated tensioning fibers to stabilize sling configurations upon implantation; longer sling arms; the addition of chevron anchors on the sling arms, which are intended to provide enhanced acute tissue fixation; Tyvek liners to prevent the chevrons from tearing the plastic sheath; and redesigned helical needles to allow easier tunneling particularly in patients with large body habitus.

The 2-year and 36-month reports of a multi-center study of the AdVance XP sling showed good and stable effectiveness, with 66% of patients cured (using a strict definition of no pads and 0–5 g in the 24 h pad test) and 23.4% improved at 36 months (6,33). The only unique intraoperative problem reported in this study was difficulty removing the Tyvek liners in a few cases, which resulted in over-tensioning of the AdVance XP sling.


Conclusions

AdVance transobturator sling is best suited for treatment of mild to moderate SUI in male patients, and can be used in cases of PPI, post-TURP or NLUTD. Preoperative patient selection is important: it involves exclusion and prior treatment of urethral stenosis and bladder dysfunction. Patient with prior pelvic radiation have poorer outcomes. Sling placement involves the following steps: (I) mobilization of the CS and central tendon off the CS; (II) bilateral small groin incisions for passage of the helical trocar needles; (III) correct passage of the needles so they exit at the apex of the angle between the CS and inferior pubic ramus; (IV) fixation of the broad part of the sling body to the CS; (V) firm tensioning of the sling; (VI) Placement of a Foley urethral catheter; (VII) subcutaneous tunnelling of the sling arms back toward the midline; (VIII) wound closure. Surgical technique including details and nuances gained from surgical experience and advice for avoidance of complications have been described. Management of sling failures has also been discussed, including AUS, repeat sling, urethral bulking agent, and ProACT device treatment options. The AdVance XP sling is placed in similar fashion to the AdVance sling.


Acknowledgements

None.


Footnote

Conflicts of Interest: AS Chung and OA Suarez have no conflicts of interest to declare. KA McCammon is a consultant/advisor and meeting participant/lecturer for Boston Scientific; he is involved in scientific study/trials with Allergan, Astellas, Boston Scientific and Solace.


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Cite this article as: Chung AS, Suarez OA, McCammon KA. AdVance male sling. Transl Androl Urol 2017;6(4):674-681. doi: 10.21037/tau.2017.07.29

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