AB093. C1QBP regulates YBX1 to suppress the androgen receptor (AR)-enhanced RCC cell invasion

Background: Early studies suggested that the androgen receptor (AR) might play important roles to promote the renal cell carcinoma (RCC) progression; however, the detailed mechanisms remain unclear.

Methods: IHC was used to test C1QBP and YBX1 expression. RCC cell migration and invasion was analyzed in vitro and in vivo. CO-IP was used to test the interaction between C1QBP and YBX1.

Results: We demonstrated the higher YBX1 expression with lower C1QBP expression in human RCC clinical tissues. C1QBP could interact with YBX1 to suppress the YBX1 activation. Suppression of YBX1 might result in suppressing the RCC cell invasion that involved altering the AR-modulated MMP9 signals.

Conclusions: Collectively, these data suggest that C1QBP could regulate YBX1 to suppress the AR-enhanced RCC cell invasion. Targeting this newly identified C1QBP/YBX1/AR/MMP9 signal pathway may provide a new potential therapy to better suppress RCC metastasis.

Keywords: C1QBP; YBX1; renal cell carcinoma (RCC)